DRAGEN Array provides accurate, comprehensive, and efficient genotyping, PGx CNV calling, and star allele annotation for Infinium microarrays.
DRAGEN (Dynamic Read Analysis for GENomics) Array secondary analysis is a powerful bioinformatics software for Infinium array-based assays. DRAGEN Array uses cutting-edge data analysis tools to provide accurate, comprehensive, and highly efficient secondary analysis to maximize genomic insights and meet your research needs.
Greater than 99.5% genotyping accuracy and 95% PGx CNV accuracy1. Additionally, with a few simple commands, accurately determine hard to discern pharmacogenomic (PGx) genes like CYP2D6 with greater than 98% call rate.2
PGx CNV coverage on 6 target genes across 9 target regions. PGx star allele and variant coverage across 1700+ targets for over 50 genes – detects hybrid and allele specific copy number.
Genotyping, PGx CNV calling, and star allele calling in a single platform. Genotyping variant call format (VCF) files in as little as 35 seconds per sample3, saving time for large experiments.
DRAGEN Array offers a local, command-line package (no specialized field programmable gate array (FPGA) server or hardware required) and a cloud-based package with an intuitive graphical user interface (GUI).
| Instruments | NextSeq 500 System, iScan System |
|---|---|
| Method | Targeted genotyping array, Genome-wide genotyping array, Custom array |
| Nucleic acid type | DNA |
| Species category | Human |
| Technology | Microarray |
| Variant class | Single nucleotide polymorphisms (SNPs), Chromosomal abnormalities, Copy number variants (CNVs) |
DRAGEN Array
Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.
Polygenic risk scores represent the total number of genetic variants an individual has that increase their risk of developing a particular disease.
Genomics in Drug Discovery & Development
Explore innovative genomic analysis solutions designed to inform drug discovery efforts and support development of targeted therapeutics.
Efficient analysis
Genotyping, PGx CNV calling, and star allele annotation in a single platform producing multiple output options.
DRAGEN Array cloud analysis, step 1
Navigate to 'Runs – Microarray Analysis Setup' to get started with analysis.
DRAGEN Array cloud Analysis, step 2
Set up the analysis configuration.
DRAGEN Array cloud analysis, step 3
Select sample for analysis with Import Sample Sheet, Select BeadChips, or Import IDAT Files.
View your results.
Star allele annotation
Example of a star allele annotation JSON file to be used in downstream processing. Provides supporting variants, missing variants and alleles tested.
DRAGEN Array Local - star allele annotation
20109885
Per sample analysis quota for star allele calling using DRAGEN Array Local. One per sample analysis quota is needed per sample analyzed for star allele calling using the star-allele call subcommand. DRAGEN Array Local is a command-line software with no FPGA hardware or specialized server required and is downloadable from the Illumina Support Site. Internet is required for per sample quota check.
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DRAGEN Array Cloud - star allele annotation
20109886
Per sample analysis quota for star allele calling using DRAGEN Array Cloud. One per sample analysis quota is needed per sample analyzed for star allele calling using the analysis type, DRAGEN Array – PGx – star allele calling. DRAGEN Array Cloud provides analysis kickoff using BaseSpace Sequence Hub. The BaseSpace Sequence Hub access is facilitated by an Illumina Connected Analytics (Basic, Professional, or Enterprise) annual subscription. iCredits are used to store data on the cloud platform.
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Illumina Analytics - 1 iCredit
20042038
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics Starter Pack - 1,000 iCredits
20042039
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 5,000 iCredits
20042040
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 50,000 iCredits
20042041
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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Illumina Analytics - 100,000 iCredits
20042042
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics.
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ICA Basic Annual Subscription
20044874
Illumina Connected Analytics (ICA) Basic Annual Subscription. This product includes 1 year of access to ICA Basic, including sequencing instrument connectivity, data management capabilities, and access to pre-packaged analysis tools.
ICA Professional Annual Subscription
20044876
Illumina Connected Analytics (ICA) Professional Annual Subscription. This product includes 1 year of access to ICA, including sequencing instrument connectivity, data management capabilities, access to pre- packaged tools, and the ability to create customized workflows composed of tools, pipelines, data warehouses, and notebooks.
ICA Enterprise Annual Subscription
20038994
Illumina Connected Analytics (ICA) Enterprise Annual Subscription. This product includes 1 year of access to ICA Enterprise, including sequencing instrument connectivity, data management capabilities, custom and pre-packaged analysis tools, and the Base module for data warehousing and mining. ICA Enterprise also includes optional HIPAA BAA (US-only), single sign-on (SSO), and a service level agreement (SLA).
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Advanced chemistry, optics, and informatics combine to deliver exceptional speed and data quality, outstanding throughput and scalability.
Optimized reagent kit that provides increased cluster density and read length, improving sequencing quality scores compared to earlier versions.
Enable CGP with a large pan-cancer panel covering all major variant classes plus gene signatures (TMB, MSI, and HRD) from FFPE tissue.
A fast, integrated workflow for preparing libraries for use in a wide range of sequencing applications.
Infinium Global Diversity Array (GDA) with Enhanced PGx is the most comprehensive genotyping microarray on the market for pharmacogenomics research.
Order an iScan System today. Speak to a representative for information on pricing, availability, and more.
A secure, scalable bioinformatics platform for seamless sequencer integration and flexible workflows.
iCredits are used to purchase data storage and analysis within the Illumina cloud software ecosystem. One iCredit is equal to one US dollar (USD).
References
1,2,3 - Illumina data on file, 2023.
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