Human Microbiome Analysis with NGS

Human microbiome analysis is the study of microbial communities found in and on the human body. The goal of human microbiome profiling studies is to understand the role of microbes in health and disease. Next-generation sequencing (NGS) has fueled studies capable of surveying the genomes of entire microbial communities, including those of unculturable organisms.

Previously, studying human microbiome samples relied on time- and labor-intensive microbiology techniques of growing and isolating individual organisms followed by phenotypic or genotypic analysis. Microbial community profiling within a single sample was not possible with these older methods.

Microbial transcriptomics, or metatranscriptomics, provides key insights into the expressed RNAs encoded by a group of organisms in a complex sample. High-quality metatranscriptomics data enables researchers to quantify gene expression changes, predict resistance or susceptibility to specific treatments, understand host-pathogen immune interactions, and track disease progression.

The Time is Now for Microbiome Studies

NGS-based whole-genome shotgun sequencing and transcriptomics methods provide researchers and pharmaceutical companies with data to refine drug discovery and development.

NGS is Revealing the Mysterious World of Microbes

Researchers at Microba are investigating the genomes of microbes to improve our understanding of human health, disease, and microbial evolution.

How Microbiome Multi-Omics Can Bolster Human Health

Sequencing technologies are enabling a deeper analysis of the gut microbiome. Researchers can now explore what our microbial inhabitants are doing and how they contribute to, or protect from, disease.