Informatics Products

Local Run Manager

Easily create sequencing runs, monitor run status, analyze sequencing data, and view results

Integrated data analysis

Local Run Manager software is an integrated solution designed to create sequencing runs, monitor run status, analyze sequencing data, and view results. It provides a range of automated data analysis tools for a wide range of applications, such as amplicon sequencing, targeted sequencing, and more. 

  • Perform data analysis using various analysis modules

  • Generate comprehensive easy-to-interpret PDF reports 

  • Record sample and input files, such as manifests and reference genomes  

  • View analysis metrics upon completion of analysis

 

Compatible instruments

Local Run Manager software integrates with instrument control software and can be directly accessed on the MiniSeq and iSeq 100 Systems through a web browser. An off-instrument version is available and compatible with the iSeq 100, MiniSeq, MiSeq, and NextSeq 550 Systems.

Find compatible library prep kits

Most Local Run Manager analysis modules will prompt you to select a library prep kit for a given run. Find out which kits are compatible with each Local Run Manager software analysis module.

View compatible kits

Featured Local Run Manager modules

DNA Amplicon Analysis Module

Enables streamlined variant detection of AmpliSeq for Illumina DNA and TruSeq Amplicon panels sequenced on Illumina sequencing systems. 

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System
  • NextSeq 550 System

DNA Enrichment Analysis Module

Aligns reads against a whole genome reference and performs variant analysis for specified regions of interest.

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

Generate FASTQ Analysis Module

Generates demultiplexed FASTQ files for further downstream analysis.

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System
  • NextSeq 550 System

Library QC Analysis Module

This module evaluates the abundance, fragment length, and sample quality of DNA libraries. The Library QC workflow provides a high-level report of the characteristics of each DNA sample. 

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

Oncology Gene Panel 170 Analysis Module

Supports run setup, sequencing, and analysis of prepared DNA and RNA libraries generated from the Oncology Gene Panel 170 IUO/PEO assay.

Compatible instruments:

  • NextSeq 550Dx Instrument

PCR Amplicon Analysis Module

Aligns reads against a whole genome reference and performs variant analysis for specified regions of interest. This workflow is intended for analysis of PCR amplicons that have been fragmented using Nextera fragmentation.

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

Resequencing Analysis Module

Aligns reads and performs variant analysis for whole-genome sequencing of small genomes.

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

RNA Amplicon Analysis Module

Enables streamlined differential expression analysis of AmpliSeq for Illumina RNA targeted panels sequenced on Illumina sequencing systems.

Compatible instruments:

  • iSeq 100 System
  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

RNA Fusion Analysis Module

Aligns reads and detects fusions of RNA libraries prepared with the TruSight RNA Fusion Panel kit.

Compatible instruments:

  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

Small RNA Analysis Module

Aligns read and output hits. Performs optional novel precursor discovery and pairwise differential expression analysis.

Compatible instruments:

  • MiniSeq System
  • MiSeq System 
  • NextSeq 550 System

TruSight Oncology 500 Analysis Module

Analyzes and generates a filtered report for samples prepared using the TruSight Oncology 500 assay for > 500 genes associated with solid tumors.

Compatible instruments:

  • NextSeq 550 Instrument

TruSight Tumor 15 Analysis Module

Analyzes and generates a filtered report for samples prepared using the TruSight Tumor 15 assay for 15 genes associated with solid tumors. 

Compatible instruments:

  • MiniSeq System
  • MiSeq System

16S Metagenomics Analysis Module

Classifies organisms from a metagenomic sample by amplifying specific regions in 16S ribosomal RNA. This workflow is exclusive to prokaryotes.

Compatible instruments:

  • MiniSeq System
  • MiSeq System

Related information

Additional resources

Find more information about Local Run Manager including training, frequently asked questions, technical bulletins, and more. 

Local Run Manager training resources

Local Run Manager: How do I use a custom library prep kit?

Local Run Manager security announcement

Download analysis modules or get support

Download a specific analysis software module of interest, or access Local Run Manager technical support information.

Download Local Run Manager modules

Access Local Run Manager support

Speak with a specialist

Contact us to learn more about the different Local Run Manager modules and which ones are right for your needs.