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Correlation Engine
An interactive omics knowledge base that analyzes private omics data with highly curated public data to help researchers put their data into biological context.
Overview
Correlation Engine is one of the largest biological databases in the world, providing life science researchers with unprecedented access to vast numbers of high-quality whole-genome analyses and insightful scientific tools. The knowledge base enables novel discoveries by interrogating billions of data points derived from standardized analyses of whole-genome studies.
Correlation Engine offers:
Accelerate your journey from omic data to discovery
Quickly correlate and ask questions about your data with Correlation Engine’s 256K curated omics signatures.
Specifications
| Instruments | MiSeq System, NextSeq 550 System, NextSeq 2000 System, NextSeq 1000 System, MiSeqDx in Research Mode, MiniSeq System, NextSeq 550Dx in Research Mode, NovaSeq X System, NextSeq 500 System, iScan System, NovaSeq 6000 System, NovaSeq X Plus System |
|---|---|
| Software format | Cloud, Cloud |
| Technology | Microarray, Sequencing |
Compliance certifications
Compliance certificates
ISO 27001 Certified by Schellman
Illumina has received ISO 27001 certification of its information security management system (ISMS) supporting Correlation Engine. This certification ensures that sensitive data contained or collected by these solutions are protected. The certification was performed by Schellman, an ANSI National Accreditation Board (ANAB) and United Kingdom Accreditation Service (UKAS) accredited certification body based in the US.
ISO 27701 Certified by Schellman
Correlation Engine is compliant with global and local data privacy and requirements with 27701:2019 certification.
GDPR
Correlation Engine features multiple system controls that you can use to manage authorization, authentication, and data control, including deletion as needed. Access logs are retained for seven years. These features help researchers ensure compliance with the General Data Protection Regulation.
Applications
Correlation Engine delivers an easy-to-use interactive genomics analysis platform that puts private data in biological context with highly curated public data. Applications support early-stage research to identify mechanisms of disease, drug targets, and prognostic or predictive biomarkers.
Software product portfolio
Lab
A highly customizable laboratory information management system that allows genomics labs to track samples and manage workflows efficiently and securely.
Run
Easy-to-use cloud-based genomic run management and bioinformatics compute and storage environment for secure, high-performing sequencing operations.
Analytics
Accurate, comprehensive, and efficient secondary analysis of next-generation sequencing (NGS) data.
BaseSpace Sequence Hub offers a wide variety of NGS data analysis apps for common Illumina sequencing methods.
A secure, scalable bioinformatics platform for seamless sequencer integration and flexible workflows.
Insights
Correlation Engine
An interactive omics knowledgebase that puts private omics data in biological context with highly curated public data.
Enable high-efficiency data interpretation workflows for rare disease genomics and other germline research applications, with the support of explainable AI and user-configured automation.
Key use cases
Biomarker discovery and validation
Identify key biomarkers and discover which genes in signatures provide the best markers for major disease areas, optimal therapeutic targets, and mechanisms of action.
Drug repurposing
Look for inverse correlations to discover gene–disease compound links that indicate a new purpose for a drug.
University-wide research libraries
Enable researchers campus-wide to query and use highly curated public omics data to contextualize their data to accelerate their research projects and generate publications.
Drug safety and toxicogenomics
Leverage public toxicology studies to evaluate compound signatures and use curated studies or the meta-analysis app to uncover overlaps with other known toxicogenomic signatures.
Related applications and methods
Illumina provides an innovative portfolio of NGS systems, products, and services for many phases of the drug development pipeline.
Use multiomics profiling to multiply discovery power and better connect genotype to phenotype.
Comprehensive analysis solutions for SARS-CoV-2 surveillance
Accelerate coronavirus detection and identification, perform host response studies, simplify your sample tracking, and contribute to public databases.
Documentation
Product literature
Figures
Correlate across data types
Novel correlations and associations are quickly identified for a given query, revealing data-driven connections between genes, diseases, compounds, tissues, and pathways.
Body Atlas
Body Atlas provides insights about where a gene is expressed and its expression level within that location.
Disease Atlas
Disease Atlas delivers correlations between diseases, traits, and conditions associated with queried data.
Pharmaco Atlas
Pharmaco Atlas aids in the discovery of compounds, genomic and epigenomic responses to compounds, and treatments associated with queried data.
Resources
Our variant annotation and analysis software tools can help researchers extract and report biological insights from large volumes of genomic data.
Explore sophisticated multiomic analysis workflows leveraging Correlation Engine.
FAQs
No. Currently Correlation Engine supports only human biology and animal model systems. However, the platform can be used to analyze host response to infection.
Correlation Engine supports RNA expression (RNA-Seq), genotyping/SNP GWAS, DNA protein interaction analysis, somatic mutation analysis, and DNA methylation analysis.
Correlation Engine combines an interactive and easy-to-use interface and pre-built workflows with a comprehensive set of high-quality curated public data, enabling rapid results so that users can move forward to the next experiment without delay.
There are over 23,000 studies in Correlation Engine. Studies in Correlation Engine are updated weekly.
Correlation Engine recognizes most public and standard commercial platform identifiers, including NCBI Gene IDs, gene symbols, NCBI accession numbers, ENSEMBL IDs, RefSeq identifiers, IPI ids, and custom IDs from most Affymetrix, Illumina, Agilent, and GE Healthcare platforms.
Correlation Engine uses proprietary rank-based statistics to compute associations between the data you import and all other experimental data. This allows you to place your experimental results within the context of the world's experiments to validate results, discover novel associations, and design new experiments. It correlates your data with all biogroups, allowing discovery of common features among genes or proteins that comprise your study.
Correlation Engine indexes over 19 million abstracts from PubMed and over 130,000 full-text publications from PubMed Central. For literature searches, Correlation Engine uses several heuristics, including:
- An extensive ontology with relationships between terms and synonyms and a term hierarchy
- A customized, domain-specific stop word list and analyzer that emphasizes ontology terms
- The overall authority of the journal in which the paper was published
- Date of publication
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Results
Interested in trying Correlation Engine?
Academic researchers with a .edu email account can start a free 30-day trial by registering here. Alternatively, if you are a COVID-19 researcher interested in a free 6-month trial, or a commercial customer interested in a purchase, use the sign-up option below.
Interested in trying Correlation Engine?
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Speak with a specialist
Reach out for information about our products and services, or get answers to questions about our technology.
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