Illumina Connected Insights

Streamline oncology clinical research with Illumina Connected Insights

Comprehensive insights and automation to support variant interpretation for diverse applications and variant types at scale

Confidently connect your genomic analysis workflows

The Connected Insights product line harnesses extensive knowledge sources via powerful API-integrations for streamlined variant interpretation, including prioritization of relevant clinical trials, drug labels, and guidelines for clinical research. Control over your standardized workflows enables flexibility, and automation speeds your time to relevant insights with procedural consistency. Connected Insights helps you address the interpretation bottleneck and move our understanding of disease forward.


Harness the power of API-integrated knowledge sources into a single solution to bring insights to diverse applications. Automate your interpretation workflows with customizable presets.


Remove unnecessary touchpoints and manual data movement for your NGS workflow, from sequencing through draft report. Seamless and secure, upstream and downstream, directly integrate with the latest DRAGEN secondary analysis.

Powered for growth

Keep pace with comprehensive test options that enable diverse variant and biomarker analyses. Expand assay applications and scale volume without increasing headcount and interpretation resources.

We help you achieve


Generate insights using 45+ knowledge sources including JAX-CKB™, CIViC and OncoKB (coming soon) via API-calling.

Private curation

Grow and manage your lab's private curated knowledge.


From data upload to report generation – configure your settings and automate for a streamlined experience with minimum touchpoints.


Evolve with confidence across assays and applications—from panels to genomes and transcriptomes, from tissue to liquid biopsy and heme.


Configure regional content, preferences and language to meet regional needs.


Employ security-first infrastructure and conform to privacy and compliance software requirements and regulations.

Key applications

DNA variants

Identify key DNA variant types (SVs, MNVs, exon-level CNVs, indels, fusions, tandem repeats, LOH) relevant in multiple disease types and across a variety of NGS assays.

RNA variants

Analyze variants from RNA or transcriptomics (fusions, splice variants, and soon expression levels) to gain a deeper and more comprehensive understanding of malignancies.

Biomarker signatures

Uncover more insights by interpreting genome- wide pan-cancer biomarker signatures (TMB, MSI, HRD) with increasing relevance to precision medicine.

NGS workflow with Illumina Connected Insights

Rapid, interpretable data for meaningful insights



Prepare libraries for somatic oncology panels or other compatible applications.


Sequence libraries using any Illumina or other sequencing platform.


Call variants with DRAGEN or other secondary analysis tools to generate VCF (Variant Call Format) output.


Input VCF files to Connected Insights to enable generation of insights and case reporting.

High standards of data privacy and protection

To meet the most stringent security requirements, Illumina Connected Insights platform is built with security and compliance at its core. Read the security brief for more details.


Workflow configuration options

Configure once with a fine level of granularity to match your lab’s standard operating procedure (SOP). Accelerate your workflow by leveraging automation configured according to your SOP.

Lab curation

Grow your lab’s private knowledge base with every case and instantly interpret cases against your historical experience. Your curated knowledge is private, secure, and always at your fingertips.

Streamlined reporting

Customize based on lab name, lab branding, sections, fields, and more. Easily edit reports without data reingestion. Export reports in any language.

Software preview

Save time with automated data upload after one-time configuration. Enjoy workflows with no touchpoints from Illumina sequencers.

Quickly view key findings, coverage, and QC summary in a consolidated format. Intuitively access deeper evidence sources with a streamlined user interface design.

Accelerate turnaround time by automating your exact SOP from variant QC and prioritization to interpretation and reporting by configuring disease, guideline, and lab-specific settings.

Deepen your insights with cutting-edge visualizations –explore genome view, DNA and RNA coverage plots, variant allele frequency (VAF) distribution plots, and more.

Product content and related resources

Illumina Connected Insights brochure

Discover how the Connected Insights product line can streamline user-defined variant interpretation research workflows and reduce the time it takes to generate meaningful insights, all with a single-vendor workflow.

Illumina Connected Insights video

Watch this video to understand how the Connected Insights product line can connect various knowledge sources to streamline data interpretation operations for critical insights.

Illumina Connected Insights data sheet

Read how Connected Insights streamlines, integrates, and powers molecular laboratories for scale and growth.

Connecting knowledge to clinical data at scale

Key opinion leaders discuss the ongoing challenges and future potential of NGS in clinical oncology.

Illumina Connected Insights security brief

Learn how Connected Insights employs key security and privacy features to protect sensitive NGS data.

Related solutions

Comprehensive panels

Comprehensive genomic profiling (CGP) uses a single assay to assess hundreds of genes including relevant cancer biomarkers, as established in guidelines and clinical trials, for therapy guidance.

Whole-exome sequencing

Focus on sequencing coding regions, which frequently contain mutations that affect tumor progression, for a cost-effective approach.

Whole-genome sequencing

Get a genome-wide view of somatic mutations and other genomic alterations present in cancer tissue and discover novel cancer-associated variants.

Related products

Clarity LIMS software

A highly customizable laboratory information management system that allows genomics labs to track samples and manage workflows efficiently and securely.

Illumina Connected Analytics Ordering

Operationalize informatics and drive scientific insights with Illumina Connected Analytics. Contact us for information on pricing, subscriptions, and more.

Ready to connect with a genomic scientist?

Discuss your workflow to learn how you can streamline your NGS operations and power your lab for growth using Illumina Connected Insights.