NGS in Oncology

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Genomic solutions to change how cancer will be identified and treated

Benefits of NGS in Oncology

As genomics-focused pharmacology begins to play a greater role in cancer treatment, next-generation sequencing (NGS) has emerged as a valuable method for obtaining a deeper and more accurate look into the molecular underpinnings of individual tumors. With targeted therapies becoming the new standard of care in oncology, NGS-driven companion diagnostics are widely seen as driving the selection of treatments to optimize patient outcomes in the future.

Compared to traditional methods, NGS offers advantages in accuracy, sensitivity, and speed that has the potential to make a significant impact on the field of oncology. Because NGS can assess multiple genes in a single assay, it eliminates the need to order multiple tests to identify the causative mutation.

This multigene approach decreases the time to answer, providing a more economical solution and reducing the risk of exhausting precious clinical samples. In addition, NGS can provide high sensitivity, enabling the detection of mutations present at as little as 5% of the DNA isolated from a tumor sample.

NGS has the potential to change the future of oncology and advance the promise of personalized medicine. We invite you to learn more by examining the resources collected here.

Introduction to NGS in Oncology
Introduction to NGS in Oncology

Learn more about how NGS technology works and the advantages it offers over traditional methods in this in-depth introduction tailored to molecular pathologists.

View Intro for Pathologists
Lung Cancer

Identifying RET Alterations in Non-Small Cell Lung Cancer

Jaclyn Hechtman, MD, Associate Attending Pathologist at Memorial Sloan Kettering Cancer Center, discusses the relevance of RET alterations in non-small cell lung cancer and the pros and cons of different technical approaches to identify RET fusions and single-nucleotide variants.

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Comprehensive Genomic Profiling (CGP)

This next-generation sequencing approach consolidates hundreds of cancer-related biomarkers, including different variant types, into a single assay. Explore the benefits and find out how it compares to other common cancer NGS methods.

Cancer Biomarkers

Recent years have seen a rapid increase in the number of cancer biomarkers with associated targeted therapies. As the number of biomarkers increases, it is critical to find ways to maximize the ability to match patients with appropriate molecular treatment regimens.

Oncology News and Interviews

Missed opportunities for cancer patients
Missed opportunities for cancer patients

Current guidelines recommend clinical trials, so why aren’t we testing for eligibility?

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The Changing Landscape of NGS Implementation in Molecular Diagnostic Laboratories
The Changing Landscape of NGS Implementation in Molecular Diagnostic Laboratories

Key opinion leaders discuss the ongoing challenges and potential of NGS in oncology testing.

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Why more clinical labs are turning to whole-genome sequencing for cancer
Why more clinical labs are turning to whole-genome sequencing for cancer

The adoption of WGS in precision oncology is on the rise. Plus: the promise of MRD

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Applications of Precision Medicine

Learn about the growing uses of precision medicine in a broad range of areas, from cancer to genetic risk assessment, pharmacogenomics, reproductive health, and more. 

Patient in Hospital Gown
Tumor Mutational Burden (TMB)

NGS can help clinical cancer researchers estimate TMB, identify neoantigens, and study innovative therapies to boost the immune response.

ctDNA Sequencing

NGS offers the sensitivity and specificity that clinical researchers need to detect low levels of circulating tumor DNA (ctDNA) in the bloodstream.

Cancer Epigenetics

Explore the benefits of NGS and microarrays for analyzing altered methylation patterns and other epigenetic changes in cancer.

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